No, it is not possible to find out which settings were used to generate a given layout with only the information in the diagram.
However, when you import a spreadsheet with option "Layout" on tab "Presentation" set to "Circular", "Organic", or "Hierarchic", then yEd will use the settings which are displayed when you run the corresponding algorithm from yEd's "Layout" menu. I.e. if you run "Layout" -> "Hierarchic" with "Orientation" set to "Left to Right" and then import a spreadsheet file using "Hierarchic" layout, the imported diagram will be arranged from left to right as well.