extracellular extracellular 724dcfa5-ccc5-4987-9d2f-7b1e15888e51 TNF TNF-alpha Receptor ligand extracellular N/A specific 1 -1 TNF extracellular::membrane extracellular::membrane a799df64-93da-4117-bc47-3b4e6e9f8c77 TNFRSF1A TNF-R1 Generic receptor membrane N/A generic 1 -1 TNFRSF1A extracellular::membrane::cytosol extracellular::membrane::cytosol f2b20a7c-2c8e-40c1-ae68-e83dca9e74e3 ERAP1 ARTS-1 Metalloprotease cytosol N/A specific 1 -1 ERAP1 98cff9d1-bb2b-4362-8664-1229402376fe APAF1 Apaf-1 Generic binding protein cytosol N/A generic 1 -1 APAF1 039e1c48-4f52-42b5-ab63-6ab2459e4676 CASP9 Caspase-9 Protein cytosol N/A specific 1 -1 CASP9 88f2b88f-57fc-430b-afc4-83fd08173051 BRE BRE Generic binding protein cytosol N/A generic 1 -1 BRE 1af3f991-c3c2-4122-ae48-628461baada3 CYCS Cytochrome c Generic enzyme cytosol N/A generic 1 -1 CYCS 178d1ec3-1379-4899-a5e9-48bcff45fb2a DIABLO Smac/Diablo Generic binding protein cytosol N/A generic 1 -1 DIABLO 2727e7f3-758b-4406-8274-c7a44746c56d HTRA2 HtrA2 Generic protease cytosol N/A generic 1 -1 HTRA2 c057c230-84c5-4b6c-ba65-f235a2447355 CASP10 Caspase-10 Generic protease cytosol N/A generic 1 -1 CASP10 6310bda8-1ec0-42f8-9086-c759cb5c6eab CASP8 Caspase-8 Generic protease cytosol N/A generic 1 -1 CASP8 ffbbd179-89ab-4bc1-9081-7404790b819d BID jBid;tBid Generic binding protein cytosol N/A generic 1 -1 BID eafced32-11fa-45f6-b610-68dfb19346ba CASP2 Caspase-2 Generic protease cytosol N/A generic 1 -1 CASP2 c92be96c-3af0-4019-8d23-4db816c5cac4 CASP7 Caspase-7 Generic protease cytosol N/A generic 1 -1 CASP7 8099660f-78c0-41ea-bdec-384543d7778c CASP6 Caspase-6 Generic protease cytosol N/A generic 1 -1 CASP6 604d1891-f09f-47e7-b5a7-aa5e3a4ca9a7 FADD FADD Generic binding protein cytosol N/A generic 1 -1 FADD 2838bc71-5a91-4f44-b3f5-f246d206f547 **Ceramides signaling pathway **Ceramides signaling pathway Submap cytosol N/A specific 1 -1 **Ceramides signaling pathway d05161d6-b8bd-416a-a021-87e891b5bfdb CASP8AP2 FLASH Generic binding protein cytosol N/A generic 1 -1 CASP8AP2 0d273ab2-7953-4c0f-b556-538a9bfdc1d0 MAP4K2 GCK(MAP4K2) Protein kinase cytosol N/A specific 1 -1 MAP4K2 6585d73f-9c36-42b0-9029-00f8c94c7680 MAP3K1 MEKK1(MAP3K1) Protein kinase cytosol N/A specific 1 -1 MAP3K1 a785b9f5-3eab-4960-99bf-fe2d1b4cfa1d BIRC2 c-IAP1 Generic binding protein cytosol N/A generic 1 -1 BIRC2 709425fb-8993-4478-9243-b9b15f87bb48 CHUK;IKBKB IKK (cat) Protein kinase cytosol N/A specific 1 -1 CHUK;IKBKB 3b4accec-e227-4ca2-842c-6ca2d3259509 IKBKG IKK-gamma Generic binding protein cytosol N/A generic 1 -1 IKBKG 6311929a-c612-403a-86e2-3f29e24535be MAPK10;MAPK8;MAPK9 JNK(MAPK8-10) Protein kinase cytosol N/A specific 1 -1 MAPK10;MAPK8;MAPK9 4125d11b-54f6-4ba6-a77c-f8a06408e668 MAP2K4 MEK4(MAP2K4) Protein kinase cytosol N/A specific 1 -1 MAP2K4 6141b5ae-e663-47ae-a1c8-ddc210a5e79e MAP2K7 MKK7 (MAP2K7) Protein kinase cytosol N/A specific 1 -1 MAP2K7 0a65cd26-9802-431a-a361-3fc10939a00a BIRC3 c-IAP2 Generic binding protein cytosol N/A generic 1 -1 BIRC3 ecddcec9-6049-42b5-bd0b-b084bef81aca XIAP XIAP Generic binding protein cytosol N/A generic 1 -1 XIAP 5ff633e6-b58b-43ee-b56e-2fda0bac457e CRADD RAIDD Generic binding protein cytosol N/A generic 1 -1 CRADD cd9ce81e-0f56-4436-ab64-bcd949cf8ef6 RIPK1 RIPK1 Protein kinase cytosol N/A specific 1 -1 RIPK1 ded6ffec-aac1-4cfe-bc6a-b6bfaeefebb0 BAG4 SODD Generic binding protein cytosol N/A generic 1 -1 BAG4 b4c3361b-2ddb-4f86-9967-6c37ed6cea9c TRADD TRADD Generic binding protein cytosol N/A generic 1 -1 TRADD 412dc351-3674-494e-92d5-910eef9b3250 TRAF2 TRAF2 Generic binding protein cytosol N/A generic 1 -1 TRAF2 e9f20e1c-44c2-48bc-b946-64fe690373c7 CFLAR c-FLIP (S) Generic binding protein cytosol N/A generic 1 -1 CFLAR 5dc6b363-1770-41e7-b1fb-fe969ba13291 **Cell proliferation **Cell proliferation Submap cytosol N/A specific 1 -1 **Cell proliferation extracellular::membrane::cytosol::mitochondria extracellular::membrane::cytosol::mitochondria ab1c9b4b-3304-4213-8867-b62a07c13719 BAX Bax Generic binding protein mitochondria N/A generic 1 -1 BAX 52fed973-709a-4afa-a679-bc2c89617878 BCL2 Bcl-2 Generic binding protein mitochondria N/A generic 1 -1 BCL2 extracellular::membrane::cytosol::nucleus extracellular::membrane::cytosol::nucleus 4e394f21-0c96-4fc7-b69b-2e4232f61b30 **Caspase cascade **Caspase cascade Submap nucleus N/A specific 1 -1 **Caspase cascade 914974b5-68de-4451-9f47-d4f521e0d69d **Cell death **Cell death Submap nucleus N/A specific 1 -1 **Cell death cdf1a3b2-a49a-490f-bbe0-1817cc0acdf8 CASP3 Caspase-3 Generic protease nucleus N/A generic 1 -1 CASP3 b3d09f0c-032c-4a1e-9965-df7363a87efd NFKBIA;NFKBIB;NFKBIE I-kB Generic binding protein nucleus N/A generic 1 -1 NFKBIA;NFKBIB;NFKBIE 7b115192-2d6c-44da-a185-503e5562984c NFKB1;NFKB2;REL;RELA;RELB NF-kB Transcription factor nucleus N/A specific 1 -1 NFKB1;NFKB2;REL;RELA;RELB 5b9a1bd7-03ac-4a5a-8c04-bd67560e151d JUN c-Jun Transcription factor nucleus N/A specific 1 -1 JUN Activation Inhibition Activation Inhibition Activation Activation Activation Inhibition Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Inhibition Inhibition Inhibition Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Activation Inhibition Inhibition Inhibition Inhibition Activation Activation Activation Activation Activation Activation Activation Activation Inhibition Inhibition Inhibition Inhibition Inhibition Activation Activation Activation Activation